Constraint-based analysis of metabolic capacity of Salmonella typhimurium during host-pathogen interaction

Divergent Roles of Salmonella Pathogenicity Island 2 and Metabolic Traits during Interaction of S. enterica Serovar Typhimurium with Host Cells

The molecular mechanisms of virulence of the gastrointestinal pathogen Salmonella enterica are commonly studied using cell culture models of infection. In this work, we performed a direct comparison of the interaction of S. enterica serovar Typhimurium (S. Typhimurium) with the non-polarized epithelial cell line HeLa, the polarized cell lines CaCo2, T84 and MDCK, and macrophage-like RAW264.7 ce...

Chromatin Remodelling During Host-Bacterial Pathogen Interaction

Interaction of Candida albicans with an intestinal pathogen, Salmonella enterica serovar Typhimurium.

Candida albicans is an opportunistic human fungal pathogen that normally resides in the gastrointestinal tract and on the skin as a commensal but can cause life-threatening invasive disease. Salmonella enterica serovar Typhimurium is a gram-negative bacterial pathogen that causes a significant amount of gastrointestinal infection in humans. Both of these organisms are also pathogenic to the nem...

A new Salmonella typhimurium DNA host specificity.

The genetic properties of a new (hspS) host specificity of Salmonella typhimurium were investigated using bacteriophage L. Phage L is a better substrate for s-specific restriction than phage P22. Mutants deficient in s-restriction only were found at the same frequency as mutants deficient in both restriction and modification. Crosses between S. typhimurium Hfr and S. typhimurium For between Esc...

Salmonella typhimurium interations with host cells

S. typhimurium is capable of entering into phagocytic and nonphagocytic cells and functiorting as an intracellular pathogen. During invasion of epithelial cells, S. typhimurium causes membrane rffiing and actin rearrangement as it enters. It thetx targets to a specialized vacuole where it replicates. Associated with replication is the ind.uction of a unique host filamentous structure. Isolation...